Concept:
Drug hypersensitivity means an allergic reaction to a drug.
Step 1: Penicillin allergy can cause rash, urticaria, bronchospasm, or even anaphylaxis.
Step 2: If a patient has a history of hypersensitivity to penicillins, the same class should be avoided.
Step 3: Re-exposure may cause a more severe allergic reaction.
Step 4: Other antibiotics may be selected depending on infection and clinical condition.
Step 5: Therefore, penicillins should be avoided.
\[
\boxed{\text{Penicillins}}
\]