Question:
Which drug causes ocular hypotension with apnea in an infant?
Which drug causes ocular hypotension with apnea in an infant?
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Alpha-2 agonist that crosses the infant blood-brain barrier.
Updated On: Jun 23, 2026
- Latanoprost
- Timolol
- Brimonidine
- Dorzolamide
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Verified By Collegedunia
The Correct Option is C
Solution and Explanation
Step 1: The question links a glaucoma drug to lowered intraocular pressure (ocular hypotension) together with systemic apnea in an infant. The key is a drug that crosses the immature blood-brain barrier.
Step 2: Brimonidine is a relatively selective alpha-2 agonist that lowers intraocular pressure by reducing aqueous production and increasing uveoscleral outflow.
Step 3: In infants and young children, brimonidine readily crosses the blood-brain barrier and causes central nervous system depression. Reported effects include bradycardia, hypotension, hypothermia, hypotonia and apnea, so it is contraindicated in this age group.
Step 4: Latanoprost (prostaglandin analogue), timolol (beta-blocker) and dorzolamide (carbonic anhydrase inhibitor) lower IOP but are not the classic cause of apnea in infants. Hence the answer is brimonidine, option (c).
Step 2: Brimonidine is a relatively selective alpha-2 agonist that lowers intraocular pressure by reducing aqueous production and increasing uveoscleral outflow.
Step 3: In infants and young children, brimonidine readily crosses the blood-brain barrier and causes central nervous system depression. Reported effects include bradycardia, hypotension, hypothermia, hypotonia and apnea, so it is contraindicated in this age group.
Step 4: Latanoprost (prostaglandin analogue), timolol (beta-blocker) and dorzolamide (carbonic anhydrase inhibitor) lower IOP but are not the classic cause of apnea in infants. Hence the answer is brimonidine, option (c).
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