Question:
A patient with raised intraocular pressure, optic disc changes and ciliary congestion is started on a drug that lowers IOP by increasing uveoscleral outflow. Which drug is this?
A patient with raised intraocular pressure, optic disc changes and ciliary congestion is started on a drug that lowers IOP by increasing uveoscleral outflow. Which drug is this?
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Only one class works by boosting the uveoscleral pathway: the prostaglandin analogues.
Updated On: Jun 23, 2026
- Latanoprost
- Pilocarpine
- Dorzolamide
- Timolol
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The Correct Option is A
Solution and Explanation
Answer: Latanoprost.
Step 1: The question specifies the mechanism: a drug that lowers intraocular pressure by increasing uveoscleral outflow.
Step 2: Latanoprost is a prostaglandin F2-alpha analogue. It stimulates the prostaglandin FP receptor and remodels the ciliary muscle extracellular matrix, increasing aqueous outflow mainly through the uveoscleral pathway, which lowers IOP.
Why not the others: Pilocarpine (a miotic) increases trabecular (conventional) outflow. Dorzolamide (a carbonic anhydrase inhibitor) and timolol (a beta-blocker) lower IOP by reducing aqueous production, not by increasing uveoscleral outflow.
Ref: DrugBank, Latanoprost (DB00654).
Step 1: The question specifies the mechanism: a drug that lowers intraocular pressure by increasing uveoscleral outflow.
Step 2: Latanoprost is a prostaglandin F2-alpha analogue. It stimulates the prostaglandin FP receptor and remodels the ciliary muscle extracellular matrix, increasing aqueous outflow mainly through the uveoscleral pathway, which lowers IOP.
Why not the others: Pilocarpine (a miotic) increases trabecular (conventional) outflow. Dorzolamide (a carbonic anhydrase inhibitor) and timolol (a beta-blocker) lower IOP by reducing aqueous production, not by increasing uveoscleral outflow.
Ref: DrugBank, Latanoprost (DB00654).
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