Question:
Which coenzyme is required for Transamination?
Which coenzyme is required for Transamination?
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Transamination is the reaction that moves an amino group (–NH 2 ) from an amino acid onto a keto acid. It needs a special coenzyme to carry that amino group.
Updated On: Jun 24, 2026
- Co-enzyme Q
- NAD
- FAD
- Pyridoxal Phosphate (PLP)
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The Correct Option is D
Solution and Explanation
Concept:
Transamination is the reaction that moves an amino group (–NH2) from an amino acid onto a keto acid. It needs a special coenzyme to carry that amino group.
Step 1:
The coenzyme for all transamination reactions is pyridoxal phosphate (PLP), which is the active form of vitamin B6. It temporarily holds the amino group during the transfer.
Step 2:
Enzymes that do this (the transaminases, like ALT and AST) all depend on PLP. Without vitamin B6, transamination cannot proceed properly.
Step 3:
The other coenzymes have different jobs: NAD and FAD carry hydrogen/electrons in oxidation reactions, and Coenzyme Q shuttles electrons in the respiratory chain — none of them carry amino groups.
Answer: Option (4) — Pyridoxal Phosphate (PLP).
Transamination is the reaction that moves an amino group (–NH2) from an amino acid onto a keto acid. It needs a special coenzyme to carry that amino group.
Step 1:
The coenzyme for all transamination reactions is pyridoxal phosphate (PLP), which is the active form of vitamin B6. It temporarily holds the amino group during the transfer.
Step 2:
Enzymes that do this (the transaminases, like ALT and AST) all depend on PLP. Without vitamin B6, transamination cannot proceed properly.
Step 3:
The other coenzymes have different jobs: NAD and FAD carry hydrogen/electrons in oxidation reactions, and Coenzyme Q shuttles electrons in the respiratory chain — none of them carry amino groups.
Answer: Option (4) — Pyridoxal Phosphate (PLP).
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