Question:
Which class of antimalarial drugs is responsible for radical cure by killing exo-erythrocytic forms?
Which class of antimalarial drugs is responsible for radical cure by killing exo-erythrocytic forms?
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In malaria, some Plasmodium species (P. vivax and P. ovale) form dormant liver-stage parasites called hypnozoites (exo-erythrocytic forms).
Updated On: Jun 24, 2026
- 8-Aminoquinolines
- Artemisinin compounds
- Biguanides
- Phenanthrene methanols
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The Correct Option is A
Solution and Explanation
Concept:
In malaria, some Plasmodium species (P. vivax and P. ovale) form dormant liver-stage parasites called hypnozoites (exo-erythrocytic forms). "Radical cure" means eliminating these liver forms to prevent relapses, not just clearing the blood-stage infection.
How it works: The 8-aminoquinolines (such as primaquine and tafenoquine) are the only antimalarials that kill the dormant exo-erythrocytic (liver) forms, providing a radical cure and preventing relapse.
Why the other choices are wrong: Artemisinins and phenanthrene methanols (e.g. mefloquine, lumefantrine) mainly act on blood-stage parasites. Biguanides (e.g. proguanil) have causal prophylactic activity but are not the standard radical-cure agents for hypnozoites.
Answer: Option (1) — 8-Aminoquinolines provide radical cure by killing exo-erythrocytic forms. (1)
In malaria, some Plasmodium species (P. vivax and P. ovale) form dormant liver-stage parasites called hypnozoites (exo-erythrocytic forms). "Radical cure" means eliminating these liver forms to prevent relapses, not just clearing the blood-stage infection.
How it works: The 8-aminoquinolines (such as primaquine and tafenoquine) are the only antimalarials that kill the dormant exo-erythrocytic (liver) forms, providing a radical cure and preventing relapse.
Why the other choices are wrong: Artemisinins and phenanthrene methanols (e.g. mefloquine, lumefantrine) mainly act on blood-stage parasites. Biguanides (e.g. proguanil) have causal prophylactic activity but are not the standard radical-cure agents for hypnozoites.
Answer: Option (1) — 8-Aminoquinolines provide radical cure by killing exo-erythrocytic forms. (1)
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