Question

Which chromosome is responsible for the production of MIF (Mullerian inhibiting factor)?

• A. Chromosome 16
• B. Chromosome 22
• C. X chromosome
• D. Y chromosome

Hint:

MIF follows testis formation, which is switched on by SRY on which chromosome?

Answer 1

The Correct Option is D

Step 1: Mullerian inhibiting factor (MIF), also called anti-Mullerian hormone (AMH), is secreted by the Sertoli cells of the testis and causes regression of the Mullerian ducts in the male fetus. Step 2: Testis development is initiated by the SRY gene, the testis-determining factor located on the short arm of the Y chromosome. Step 3: AMH/MIF is a downstream effect of the SRY pathway, so the chromosome ultimately responsible for its production in the male is the Y chromosome. Step 4: Although the structural AMH gene and its receptor are autosomal, the production of MIF in the developing testis is driven by the Y chromosome through SRY, so the answer is the Y chromosome.