Question

Where do Call-Exner bodies occur?

• A. Granulosa cell tumor
• B. Theca cell tumor
• C. Dysgerminoma
• D. Brenner tumor

Hint:

Call-Exner bodies are eosinophilic, follicle-like rosettes formed by granulosa cells, a hallmark of granulosa cell tumor.

Answer 1

The Correct Option is A

Step 1: Define Call-Exner bodies.
Call-Exner bodies are small, round, eosinophilic spaces filled with fluid. Granulosa cells arrange themselves around these spaces in a rosette pattern, which makes the tissue look like it is trying to build tiny immature ovarian follicles.

Step 2: Tie this picture to a tumor.
This exact arrangement is the classic microscopic hallmark of a granulosa cell tumor of the ovary. The microfollicular pattern with Call-Exner bodies is one of the first things a pathologist looks for when this tumor is suspected.

Step 3: Check the other sex cord stromal and germ cell tumors.
A theca cell tumor is built of spindle shaped theca cells loaded with lipid, arranged in sheets, without follicle-like rosettes. Dysgerminoma shows large, clear, uniform cells divided into nests by thin fibrous bands carrying lymphocytes, a completely different picture. Brenner tumor has nests of transitional, bladder-like epithelium sitting in dense fibrous stroma, again no Call-Exner bodies.

Step 4: Final answer.
Call-Exner bodies are seen in
\[ \boxed{\text{Granulosa cell tumor}} \]