Question:
What role does the P-glycoprotein efflux pump play in drug absorption?
What role does the P-glycoprotein efflux pump play in drug absorption?
Show Hint
P-gp = drug efflux pump → reduces absorption → lowers bioavailability.
Updated On: May 22, 2025
- Enhances metabolism
- Inhibits absorption
- Facilitates absorption
- Has no effect on absorption
Show Solution
Verified By Collegedunia
The Correct Option is B
Solution and Explanation
P-glycoprotein (P-gp) is an efflux transporter found in intestinal epithelium that pumps drugs back into the intestinal lumen, thereby reducing their absorption and bioavailability.
Was this answer helpful?
0
0
Top TS PGECET Pharmacy Questions
- Increase in the solubility of the aqueous systems by adding large amount of additives is known as.........
- Clark's formula………
- One of the following is used as a key ingredient in hair conditioning product
- Empty capsule has moisture content in the range of ………
- Aerosol container must withstand pressures as high as 140–180 psi at ………
View More Questions
Top TS PGECET Biopharmaceutics Questions
- Select the probable mechanism of absorption of a hydrophilic drug of molecular weight 80 dalton.
- Which term describes the drug substance in two or more identical dosage forms reaches the systemic circulation at the same relative rate and to the same relative extent without significant statistical differences?
Top TS PGECET Questions
- If \( P = \begin{pmatrix} 1 & 1 & 1 \\ 0 & 1 & 2 \\ 0 & 0 & 1 \end{pmatrix} \) is the modal matrix of \( A = \begin{pmatrix} 1 & 1 & 0 \\ 0 & 2 & 2 \\ 0 & 0 & 3 \end{pmatrix} \) then the sum of all the elements of \( P^{-1}AP \) is
- If the system of equations \( kx + y + z = k - 1 \), \( x + ky + z = k - 1 \), and \( x + y + kz = k - 1 \) has infinite solutions, then \( k \) is
- The value of the integral \( \int_C (2xy - x^2) \, dx + (x^2 + y^2) \, dy \) where \( C \) is the boundary of the region enclosed by \( y = x^2 \) and \( y^2 = x \), described in the positive sense, is
- Let \( f(x) = \log x \). The number \( C \) strictly between \( e^2 \) and \( e^3 \) such that its reciprocal is equal to \( \frac{f(e^3) - f(e^2)}{e^3 - e^2} \) is
- The solution of the differential equation \( (D^2 + 2)y = x^2 \) is
View More Questions