Question:
What mechanism underlies the gastrointestinal discomfort induced by macrolides?
What mechanism underlies the gastrointestinal discomfort induced by macrolides?
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Macrolides stimulate motilin receptors → increased GI motility → cramping.
Updated On: May 22, 2025
- Histamine receptor agonist
- Adrenergic receptor agonist
- Motilin receptor agonist
- Binding to 50 S ribosomal subunit
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The Correct Option is C
Solution and Explanation
Macrolides (e.g., erythromycin) act as motilin receptor agonists, which increase gastrointestinal motility. This stimulation of gut smooth muscle contributes to the common side effect of GI discomfort.
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