Question

What is the proposed mechanism of action of artemisinin in the treatment of malaria:

• A. Inhibition of dihydrofolate reductase, interfering with folate synthesis
• B. Blocking of the Plasmodium falciparum ATPase, disrupting ion homeostasis
• C. Generation of reactive oxygen species (ROS) by cleavage of the endoperoxide bridge, leading to parasite death
• D. Inhibition of the heme polymerase enzyme, causing accumulation of toxic heme

Answer 1

The Correct Option is C

The correct option is (C): Generation of reactive oxygen species (ROS) by cleavage of the endoperoxide bridge, leading to parasite death .