Question:
What is the histological appearance of brain in Creutzfeldt-Jakob disease -
What is the histological appearance of brain in Creutzfeldt-Jakob disease -
Show Hint
Prion disease gives the grey matter a sponge-like vacuolated look.
Updated On: Jun 24, 2026
- Neuronophagia
- Spongiform change in brain
- Microabscesses
- Demyelination
Show Solution
Verified By Collegedunia
The Correct Option is B
Solution and Explanation
Step 1: Creutzfeldt-Jakob disease is a prion disease, one of the transmissible spongiform encephalopathies caused by misfolded PrP protein.
Step 2: Its classic histology is spongiform change in the grey matter. Small intracytoplasmic vacuoles develop in neurons and neuropil, involving all six cortical layers of the cerebral cortex and often the molecular layer of the cerebellum. These glassy eosinophilic vacuoles can coalesce, and neuronal loss with gliosis accompanies them.
Step 3: The distractors point to other processes. Neuronophagia and microabscesses suggest viral or bacterial encephalitis, while demyelination points to a process such as multiple sclerosis.
Step 4: The defining microscopic feature of CJD is therefore spongiform change in the brain.
Step 2: Its classic histology is spongiform change in the grey matter. Small intracytoplasmic vacuoles develop in neurons and neuropil, involving all six cortical layers of the cerebral cortex and often the molecular layer of the cerebellum. These glassy eosinophilic vacuoles can coalesce, and neuronal loss with gliosis accompanies them.
Step 3: The distractors point to other processes. Neuronophagia and microabscesses suggest viral or bacterial encephalitis, while demyelination points to a process such as multiple sclerosis.
Step 4: The defining microscopic feature of CJD is therefore spongiform change in the brain.
Was this answer helpful?
0
0
Top NEET PG Pathology Questions
- Which of the following is true regarding the Mendelian mode of inheritance?
- A child presents with intermittent jaundice and splenomegaly. There is a history of similar complaints in the elder brother. Peripheral smear shows the following finding. How will you investigate this condition?
- An African child is found to have a mass in the jaw. A biopsy of the mass was done, and it appears as shown in the image below. The child also had a translocation of t(8;14). What is the probable diagnosis?
- A child presented to the hospital with cola-colored urine, hypertension, and puffiness of eyes. Laboratory investigations were done, and creatinine was 2.5 mg/dL. Treatment was started, and despite treatment, the patient did not improve for the next 3 weeks. The creatinine value increased to 4.5 mg/dL. Which among the following electron microscopic findings will be seen in this patient ?
- A patient was transfused 4 units of blood 2 hours ago, and now she complains of chest discomfort. X-ray shows bilateral fissural thickening. Which of the following is the most probable cause ?
View More Questions
Top NEET PG Neuropathology Questions
- Identify the X ray HSG Shown below :
- The earliest feature of 3rd cranial nerve involvement in diabetes mellitus patient is :
- A male patient with recent history of RTA was brought to hospital. His CT scan was normal, but he died within three hours of admission. Autopsy revealed retraction ball appearance and petechial hemorrhages in the corpus callosum. What is the most likely diagnosis?
- A patient presents with hearing loss and balance problems. Histopathology of the lesion shows Antony A and Antony B areas and Verocay bodies. What is the most likely diagnosis?
- A child presents with visual disturbances and delayed growth. Imaging reveals a suprasellar mass, and histopathology shows wet keratin compact, eosinophilic anucleate keratin. What is the most likely diagnosis?
View More Questions
Top NEET PG Questions
- A patient hailing from Delhi presents with fever, arthralgia, and extensive petechial rash for 3 days. Lab investigations revealed a hemoglobin of 9 g/ dL, a white blood cell count of 9000 cells/mm3, a platelet count of 20000 cells/mm3, and a prolonged bleeding time. The clotting time was normal. What is the most likely diagnosis?
- Which of the following statements is true about Trichomonas vaginalis?
- A lady from West Rajasthan presented with an ulcer surrounded by erythema on the right leg. Microscopy of the biopsy from the edge of the ulcer showed organisms with dark staining nuclei and kinetoplast. What is the most likely causative agent?
- A child presents with a fever and a rash. Urine examination showed cells with owl's eye appearance. What is the most likely diagnosis?
- Infection with Clonorchis sinensis is associated with an increased risk of__?
View More Questions