Question:
What impact does replacing the decalin ring with a cyclohexane ring have on the activity of HMG-CoA reductase inhibitors?
What impact does replacing the decalin ring with a cyclohexane ring have on the activity of HMG-CoA reductase inhibitors?
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Statins: decalin ring → high affinity; cyclohexane → major activity drop.
Updated On: May 22, 2025
- 10000 fold increase in the activity
- 10000 fold decrease in the activity
- No changes in the activity
- Increase in the activity
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The Correct Option is B
Solution and Explanation
The decalin ring in statins is crucial for their interaction with HMG-CoA reductase. Replacing it with a cyclohexane ring significantly reduces hydrophobic binding and leads to a 10000-fold decrease in inhibitory activity.
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