Question:
Warthin-Finkeldey cells are seen in which disease?
Warthin-Finkeldey cells are seen in which disease?
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Grape-like multinucleated giant cells in lymph nodes point to a classic viral exanthem.
Updated On: Jun 24, 2026
- Measles
- Rubella
- Rabies
- Typhoid
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The Correct Option is A
Solution and Explanation
Step 1: Warthin-Finkeldey cells are multinucleated giant cells classically associated with measles infection.
Step 2: Measles virus invades respiratory epithelium, multiplies locally, then spreads via viremia to the reticuloendothelial system. In the prodromal phase it produces multinucleated giant cells, including Warthin-Finkeldey cells in lymphoid tissue. So the answer is measles.
Step 3: Under the microscope these cells show a large grape-like cluster of nuclei. They are found in hyperplastic lymph nodes early in measles, and can also be seen in HIV infection and Kimura disease.
Step 4: The distractors have other markers: rubella, rabies (Negri bodies in neurons) and typhoid (typhoid nodules with macrophages) do not feature Warthin-Finkeldey cells.
Step 2: Measles virus invades respiratory epithelium, multiplies locally, then spreads via viremia to the reticuloendothelial system. In the prodromal phase it produces multinucleated giant cells, including Warthin-Finkeldey cells in lymphoid tissue. So the answer is measles.
Step 3: Under the microscope these cells show a large grape-like cluster of nuclei. They are found in hyperplastic lymph nodes early in measles, and can also be seen in HIV infection and Kimura disease.
Step 4: The distractors have other markers: rubella, rabies (Negri bodies in neurons) and typhoid (typhoid nodules with macrophages) do not feature Warthin-Finkeldey cells.
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