Question:
VIPoma is associated with which syndrome?
VIPoma is associated with which syndrome?
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VIP excess gives watery diarrhoea, hypokalaemia, and achlorhydria (WDHA).
Updated On: Jun 24, 2026
- Zollinger Ellison
- Verner Morrison
- Carcinoid syndrome
- Cushing's syndrome
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Verified By Collegedunia
The Correct Option is B
Solution and Explanation
Step 1: A VIPoma is an endocrine tumour that secretes excessive amounts of vasoactive intestinal peptide (VIP). The clinical picture it produces is named the Verner-Morrison syndrome, so option b is correct.
Step 2: Excess VIP drives massive secretory diarrhoea. The classic triad is large-volume watery diarrhoea, hypokalaemia, and achlorhydria, which is why the condition is also called WDHA syndrome and pancreatic cholera. Dehydration and flushing are common too.
Step 3: In adults, about 80 to 90 percent of VIPomas arise in the pancreas; the rest are mostly VIP-secreting pheochromocytomas.
Step 4: The distractors describe different tumour syndromes. Zollinger-Ellison is caused by a gastrin-secreting gastrinoma producing peptic ulcers. Carcinoid syndrome is from serotonin-secreting tumours causing flushing, diarrhoea, and right-heart valve disease. Cushing's syndrome is from cortisol excess. None of these is the VIPoma syndrome.
Step 2: Excess VIP drives massive secretory diarrhoea. The classic triad is large-volume watery diarrhoea, hypokalaemia, and achlorhydria, which is why the condition is also called WDHA syndrome and pancreatic cholera. Dehydration and flushing are common too.
Step 3: In adults, about 80 to 90 percent of VIPomas arise in the pancreas; the rest are mostly VIP-secreting pheochromocytomas.
Step 4: The distractors describe different tumour syndromes. Zollinger-Ellison is caused by a gastrin-secreting gastrinoma producing peptic ulcers. Carcinoid syndrome is from serotonin-secreting tumours causing flushing, diarrhoea, and right-heart valve disease. Cushing's syndrome is from cortisol excess. None of these is the VIPoma syndrome.
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