Question:
The vitamin B12 level in chronic myeloid leukemia is
The vitamin B12 level in chronic myeloid leukemia is
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Excess granulocytes raise B12-binding transcobalamins, pushing serum B12 up.
Updated On: Jun 24, 2026
- Elevated
- Decreased
- Normal
- Markedly decreased
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The Correct Option is A
Solution and Explanation
Step 1: In chronic myeloid leukemia (CML) there is a huge proliferation of granulocytes and their precursors. These cells produce transcobalamin I and III (vitamin B12 binding proteins).
Step 2: The raised levels of these binding proteins increase the total serum vitamin B12 carrying capacity, so the measured serum vitamin B12 level is elevated.
Step 3: Other characteristic laboratory findings in CML include a raised lactate dehydrogenase (LDH) and a low leukocyte alkaline phosphatase (LAP/ALP) score, which helps distinguish CML from a leukemoid reaction.
Step 4: Hence the vitamin B12 level in CML is elevated.
Step 2: The raised levels of these binding proteins increase the total serum vitamin B12 carrying capacity, so the measured serum vitamin B12 level is elevated.
Step 3: Other characteristic laboratory findings in CML include a raised lactate dehydrogenase (LDH) and a low leukocyte alkaline phosphatase (LAP/ALP) score, which helps distinguish CML from a leukemoid reaction.
Step 4: Hence the vitamin B12 level in CML is elevated.
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