Step 1: Use the formula for the sum of squares.
The sum of the first \( n \) squares is given by:
\[
S = \frac{n(n+1)(2n+1)}{6}
\]
For \( n = 100 \), substitute the value to find the sum.
Step 2: Conclusion.
The sum of squares of the first 100 numbers results in \( 99 \times 2^{100} + 1 \).
Final Answer:
\[
\boxed{99 \times 2^{100} + 1}
\]