Step 1: Recognize the series form.
The given series is
\[
S = \sum_{n=1}^{\infty} \frac{(-1)^{n+1} \pi^{2n+1}}{2^{2n+1} (2n)!}
\]
This resembles the series expansion for the sine function, which is given by:
\[
\sin(x) = \sum_{n=0}^{\infty} \frac{(-1)^n x^{2n+1}}{(2n+1)!}
\]
Thus, the given series is a modification of the sine series.
Step 2: Express the series in terms of sine.
We can rewrite the series by factoring out \( \pi \) from the powers of \( \pi^{2n+1} \) and simplifying the factorials:
\[
S = \pi \sum_{n=1}^{\infty} \frac{(-1)^{n+1} \pi^{2n}}{2^{2n+1} (2n)!}
\]
This can be rewritten as a modified sine series form.
Step 3: Simplify and match with known series.
Recognizing the structure of the modified sine series, we find that the sum converges to:
\[
S = \frac{\pi}{2}
\]
Final Answer:
\[
\boxed{\frac{\pi}{2}}
\]