Question

The suitable reagent combination for the following transformation

is

• A. (i) meta-chloroperbenzoic acid (m-CPBA); (ii) NaOH; (iii) aq. HCl
• B. (i) OsO₄; (ii) aq. HCl
• C. (i) I₂/NaOH; (ii) aq. HCl
• D. (i) dimethyldioxirane (DMDO); (ii) aq. HCl

Answer 1

The Correct Option is C

The transformation shown is a reduction process, where the methyl ketone group (Me−C−O) is reduced to a hydroxyl group (Me−C−OH).

• (A) m-CPBA (meta-chloroperbenzoic acid) is typically used for electrophilic additions and not for this transformation. Hence, this option is incorrect.
• (B) Osmium tetroxide (OsO₄) in aqueous acid typically catalyzes syn-dihydroxylation reactions on alkenes but is not relevant for the described transformation.
• (C) The combination of I₂ (Iodine) and NaOH (sodium hydroxide) is appropriate for the reduction of the methyl ketone to the corresponding alcohol, making option (C) the correct answer.
• (D) DMDO is a reagent used for oxidation reactions, not for reducing ketones to alcohols, making this option incorrect.

Thus, the correct reagent combination is option (C).