Question:

The reason for “drug induced poisoning” is :

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Poisoning occurs when the drug permanently blocks the enzyme so that the substrate cannot bind.
Updated On: Nov 11, 2026
  • Binding reversibly at the active site of the enzyme
  • Bringing conformational change in the binding site of enzyme
  • Binding irreversibly to the active site of the enzyme
  • Binding at the allosteric sites of the enzyme
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The Correct Option is C

Solution and Explanation

Enzyme inhibitors that bind reversibly at the active site are competitive inhibitors and are the normal, useful mode of drug action: the substrate can displace the drug.
When a drug binds irreversibly to the active site (covalently), the enzyme is permanently blocked and cannot catalyse its reaction; this leads to drug-induced poisoning. Allosteric binding changes the shape of the active site but is the reversible regulatory route. Hence option (3).
Answer: (3) Binding irreversibly to the active site of the enzyme
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