Question:
The most important conjugating agent in Phase II metabolism is
The most important conjugating agent in Phase II metabolism is
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Phase II metabolism (conjugation) is the step where the body attaches a large, water-soluble molecule to a drug or its Phase I product. This makes the drug more water-soluble and easier to excrete in urine or bile.
Updated On: Jun 24, 2026
- Glycine
- Acetic acid
- Sulfuric acid
- Glucuronic acid
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The Correct Option is D
Solution and Explanation
Concept:
Phase II metabolism (conjugation) is the step where the body attaches a large, water-soluble molecule to a drug or its Phase I product. This makes the drug more water-soluble and easier to excrete in urine or bile. Several conjugating agents exist, but one is used far more often than the others.
Step 1: Glucuronidation — the attachment of glucuronic acid (supplied by UDP-glucuronic acid) — is by far the most common and quantitatively most important Phase II conjugation reaction in the body. It can act on many different functional groups (–OH, –COOH, –NH2, etc.).
Step 2: While glycine, acetic acid (acetylation), and sulfate (sulfation) are also Phase II conjugating agents, they are used for fewer drugs compared to glucuronic acid.
Answer: Option (4) — The most important conjugating agent in Phase II metabolism is Glucuronic acid. (4)
Phase II metabolism (conjugation) is the step where the body attaches a large, water-soluble molecule to a drug or its Phase I product. This makes the drug more water-soluble and easier to excrete in urine or bile. Several conjugating agents exist, but one is used far more often than the others.
Step 1: Glucuronidation — the attachment of glucuronic acid (supplied by UDP-glucuronic acid) — is by far the most common and quantitatively most important Phase II conjugation reaction in the body. It can act on many different functional groups (–OH, –COOH, –NH2, etc.).
Step 2: While glycine, acetic acid (acetylation), and sulfate (sulfation) are also Phase II conjugating agents, they are used for fewer drugs compared to glucuronic acid.
Answer: Option (4) — The most important conjugating agent in Phase II metabolism is Glucuronic acid. (4)
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