Question:
The most classical symptom of VIPoma is:
The most classical symptom of VIPoma is:
Show Hint
Remember WDHA - the very first letters describe high-volume watery diarrhea.
Updated On: Jun 24, 2026
- Gall stones
- Secretory diarrhea
- Steatorrhea
- Flushing
Show Solution
Verified By Collegedunia
The Correct Option is B
Solution and Explanation
Step 1: A VIPoma is a pancreatic endocrine tumor that secretes large amounts of vasoactive intestinal peptide (VIP). It is also called Verner-Morrison syndrome, pancreatic cholera, or WDHA syndrome.
Step 2: VIP stimulates small intestinal chloride and water secretion. The hallmark is therefore a large-volume secretory diarrhea that persists even during fasting and is almost always more than 1 litre per day, often more than 3 litres per day.
Step 3: This drives the WDHA triad: Watery Diarrhea, Hypokalemia, and Achlorhydria. So the single most classical symptom is the secretory diarrhea, making option b correct.
Step 4: Why not the others: flushing occurs but only in about 20 percent of patients, steatorrhea is usually absent because malabsorption is not the mechanism, and gallstones are linked to somatostatinoma rather than VIPoma.
Step 2: VIP stimulates small intestinal chloride and water secretion. The hallmark is therefore a large-volume secretory diarrhea that persists even during fasting and is almost always more than 1 litre per day, often more than 3 litres per day.
Step 3: This drives the WDHA triad: Watery Diarrhea, Hypokalemia, and Achlorhydria. So the single most classical symptom is the secretory diarrhea, making option b correct.
Step 4: Why not the others: flushing occurs but only in about 20 percent of patients, steatorrhea is usually absent because malabsorption is not the mechanism, and gallstones are linked to somatostatinoma rather than VIPoma.
Was this answer helpful?
0
0
Top NEET PG Medicine Questions
- Identify the condition associated with the murmur in the image below
- A young man came to the medical OPD with complaints of early morning backache and stiffness, which improves on exercise, and persistent red eyes. On examination, lung expansion was less than 3 cm. X-ray is shown in the image given below.
What is the most probable diagnosis? - A patient with hyperkalemia and elevated urea levels underwent dialysis. Towards the end of the session, she became drowsy and had a sudden seizure episode. On examination, thepatient was hypotensive. What is the treatment for this condition?
- A female patient presents to the emergency department with severe restlessness, palpitations, and tremors. She is a known case of bronchial asthma. On examination, the neck looksswollen. Blood pressure is elevated, and tachycardia is noted. ECG shows atrial fibrillation.Which of the following drugs is used for immediate management in this patient?
- A 30-year-old male is found to be positive for HBsAg and HBeAg and is diagnosed with chronic hepatitis B. The patient’s viral load was 2x 100000 and SGPT is found to be doubled. What is the appropriate management in this patient? SGPT-Serum glutamate pyruvate transaminase
View More Questions
Top NEET PG VIPoma - WDHA syndrome Questions
Top NEET PG Questions
- A patient hailing from Delhi presents with fever, arthralgia, and extensive petechial rash for 3 days. Lab investigations revealed a hemoglobin of 9 g/ dL, a white blood cell count of 9000 cells/mm3, a platelet count of 20000 cells/mm3, and a prolonged bleeding time. The clotting time was normal. What is the most likely diagnosis?
- Which of the following statements is true about Trichomonas vaginalis?
- A lady from West Rajasthan presented with an ulcer surrounded by erythema on the right leg. Microscopy of the biopsy from the edge of the ulcer showed organisms with dark staining nuclei and kinetoplast. What is the most likely causative agent?
- A child presents with a fever and a rash. Urine examination showed cells with owl's eye appearance. What is the most likely diagnosis?
- Infection with Clonorchis sinensis is associated with an increased risk of__?
View More Questions