Question

The major product formed in the following reaction is

• A.
• B.
• C.
• D.

Answer 1

The Correct Option is A

The reaction given involves the treatment of the compound with bromine (Br₂) in the presence of sodium hydroxide (NaOH) under heat (Δ). This is a classic example of the Hofmann Bromamide Degradation Reaction.

Steps in the Reaction

1. Amide Group Conversion: The amide group (-CONH2) undergoes degradation in the presence of Br₂/NaOH, forming a primary amine (-NH2).

2. Retention of Other Groups: The ester group (-COOCH3) remains intact during this reaction as it does not participate in the Hofmann degradation.

3. Formation of the Product: The resulting product is a compound where the -CONH2 group is replaced by a -NH2 group, while the ester group remains unchanged.

Major Product

The major product formed in this reaction is:

Cyclohexanone derivative with an amine group (-NH₂) and an ester group (-COOCH₃) intact.

Key Points

• This reaction selectively degrades the amide group to a primary amine.
• The ester group remains unaltered.
• This is an example of the Hofmann Bromamide Reaction, which is widely used for amide to amine conversion.