Question

The increased sodium and chloride content in sweat and increased resorption of sodium and water from respiratory epithelium are genetic defects of

• A. Chronic myelogenous leukemia
• B. Duchenne muscular dystrophy
• C. Cystic fibrosis
• D. Thalassemia

Hint:

Cystic fibrosis leads to issues with the CFTR gene, affecting the movement of chloride and sodium ions across cell membranes, resulting in thick mucus and altered electrolyte levels, particularly in sweat.

Answer 1

The Correct Option is C

Medical Conditions and Sweat Electrolyte Levels

• Chronic Myelogenous Leukemia: This is a type of cancer that affects the blood and bone marrow and is not associated with abnormal sodium and chloride levels in sweat. Incorrect.
• Duchenne Muscular Dystrophy: This is a genetic disorder that causes muscle weakness and wasting but is not related to abnormal electrolyte levels in sweat. Incorrect.
• Cystic Fibrosis: Cystic fibrosis is a genetic disorder caused by mutations in the CFTR gene, leading to the production of thick and sticky mucus. One of the symptoms includes increased sodium and chloride content in sweat, making this the correct answer.
• Thalassemia: This is a blood disorder involving abnormal hemoglobin production and is not related to sodium and chloride levels in sweat. Incorrect.

Conclusion: The correct answer is Option C, which refers to Cystic Fibrosis.