Question

Tendon rupture or tendonitis of Achilles tendon is an adverse reaction of

• A. Fluoroquinolones
• B. Tetracyclines
• C. Cephalosporins
• D. Aminoglycosides

Answer 1

The Correct Option is A

The question is about identifying the drug class associated with an adverse reaction involving the Achilles tendon, either as tendon rupture or tendonitis. To answer this, we need to understand the potential adverse effects of the provided classes of antibiotics.

1. Fluoroquinolones: This class of antibiotics is known to cause tendon damage, including tendonitis and even tendon rupture, as an adverse reaction. The Achilles tendon is particularly susceptible. The mechanism involves interference with collagen synthesis, leading to weakening of tendons.
2. Tetracyclines: These are broad-spectrum antibiotics but are not primarily associated with tendon issues. Their adverse effects are more related to photosensitivity and teeth discoloration in children.
3. Cephalosporins: This class primarily causes gastrointestinal adverse effects and allergic reactions. Tendon damage or rupture is not a known concern with cephalosporins.
4. Aminoglycosides: These antibiotics are well known for ototoxicity (hearing loss) and nephrotoxicity (kidney damage), not for causing tendon problems.

Based on the above analysis, Fluoroquinolones is the correct answer because they are specifically known for causing tendon disorders, including tendon rupture and tendonitis, particularly affecting the Achilles tendon.