Question:
Study the following and pick up the correct statements:
I. Sex linked inheritance due to dominant genes follow criss-cross inheritance.
II. Gene responsible for haemophilia-C lies in autosomes.
III. In sickle cell anaemia in the $\beta$-chain of haemoglobin, valine is replaced by glutamic acid at 6th position.
IV. Cystic fibrosis is due to mutation in the gene located in 7th chromosome.
Study the following and pick up the correct statements:
I. Sex linked inheritance due to dominant genes follow criss-cross inheritance.
II. Gene responsible for haemophilia-C lies in autosomes.
III. In sickle cell anaemia in the $\beta$-chain of haemoglobin, valine is replaced by glutamic acid at 6th position.
IV. Cystic fibrosis is due to mutation in the gene located in 7th chromosome.
II. Gene responsible for haemophilia-C lies in autosomes.
III. In sickle cell anaemia in the $\beta$-chain of haemoglobin, valine is replaced by glutamic acid at 6th position.
IV. Cystic fibrosis is due to mutation in the gene located in 7th chromosome.
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Sickle Cell: Glutamic Acid (Glu) $\rightarrow$ Valine (Val). Remember "Glu-Val" at position 6!
Updated On: Jun 10, 2026
- I, II
- II, III
- II, IV
- I, IV
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Verified By Collegedunia
The Correct Option is C
Solution and Explanation
Step 1: Concept
Mendelian and chromosomal disorders.
Step 2: Analysis
* Statement II is correct: Haemophilia C (Factor XI deficiency) is autosomal, not sex-linked. * Statement III is incorrect: In sickle cell anaemia, glutamic acid is replaced by valine at the 6th position, not the other way around. * Statement IV is correct: Cystic fibrosis is caused by a mutation in the CFTR gene on chromosome 7.
Step 3: Conclusion
Statements II and IV are correct.
Final Answer: (C)
Mendelian and chromosomal disorders.
Step 2: Analysis
* Statement II is correct: Haemophilia C (Factor XI deficiency) is autosomal, not sex-linked. * Statement III is incorrect: In sickle cell anaemia, glutamic acid is replaced by valine at the 6th position, not the other way around. * Statement IV is correct: Cystic fibrosis is caused by a mutation in the CFTR gene on chromosome 7.
Step 3: Conclusion
Statements II and IV are correct.
Final Answer: (C)
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