Question

Russell bodies are found in -

• A. Multiple myeloma
• B. Gonadal tumor
• C. Parkinsonism
• D. Intracranial neoplasms

Hint:

These eosinophilic immunoglobulin inclusions belong to plasma cells.

Answer 1

The Correct Option is A

Step 1: Russell bodies are rounded eosinophilic cytoplasmic inclusions made of accumulated immunoglobulin. They form in plasma cells that synthesise and secrete excess immunoglobulin in a dysregulated way.

Step 2: Multiple myeloma is a malignant plasma cell tumour, so it is the classic setting for these inclusions. The same disturbed immunoglobulin handling also produces flame cells (fiery red cytoplasm), Mott cells (multiple blue grape-like droplets), crystalline rods and Dutcher bodies (the intranuclear counterpart of Russell bodies).

Step 3: The other options do not involve plasma cells. Gonadal tumours, Parkinsonism (which shows Lewy bodies) and intracranial neoplasms have their own distinct inclusions but not Russell bodies.

Step 4: Since Russell bodies are a plasma cell finding, the correct answer is multiple myeloma.