Question

Regarding neurofibromatosis, all are true except:

• A. Autosomal recessive
• B. Associated with cataract
• C. Scoliosis
• D. Multiple fibroma

Hint:

Is neurofibromatosis dominant or recessive?

Answer 1

The Correct Option is A

Step 1: Neurofibromatosis comprises two distinct disorders, NF1 and NF2, whose genes lie on different chromosomes (NF1 on chromosome 17, NF2 on chromosome 22). Both are inherited in an autosomal DOMINANT pattern, not autosomal recessive.

Step 2: Because the question asks for the exception, option a (autosomal recessive) is the wrong statement and is therefore the answer.

Step 3: The other options are genuine features. NF2 is associated with juvenile posterior subcapsular cataract (option b), scoliosis is a recognised skeletal complication (option c), and multiple neurofibromas, the classic skin tumours, define NF1 (option d).