Question:
Pulmonary fibrosis with skin pigmentation is a characteristic adverse effect of
Pulmonary fibrosis with skin pigmentation is a characteristic adverse effect of
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Anticancer drugs often have characteristic dose-limiting toxicities. Recognising the signature side effect of each drug is a common exam point.
Updated On: Jun 24, 2026
- Doxorubicin
- Cyclophosphamide
- Bleomycin
- Cisplatin
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The Correct Option is C
Solution and Explanation
Concept:
Anticancer drugs often have characteristic dose-limiting toxicities. Recognising the signature side effect of each drug is a common exam point.
Step 1: Bleomycin is well known for causing pulmonary fibrosis (a serious, sometimes fatal lung toxicity) and skin changes including hyperpigmentation, hyperkeratosis and flagellate dermatitis. These two together are its hallmark adverse effects.
Why the other choices are wrong: Doxorubicin's signature toxicity is cardiomyopathy. Cyclophosphamide classically causes haemorrhagic cystitis. Cisplatin is notable for nephrotoxicity and ototoxicity. None of these typically causes the lung-fibrosis-plus-pigmentation combination.
Answer: Option (3) — Bleomycin causes pulmonary fibrosis with skin pigmentation. (3)
Anticancer drugs often have characteristic dose-limiting toxicities. Recognising the signature side effect of each drug is a common exam point.
Step 1: Bleomycin is well known for causing pulmonary fibrosis (a serious, sometimes fatal lung toxicity) and skin changes including hyperpigmentation, hyperkeratosis and flagellate dermatitis. These two together are its hallmark adverse effects.
Why the other choices are wrong: Doxorubicin's signature toxicity is cardiomyopathy. Cyclophosphamide classically causes haemorrhagic cystitis. Cisplatin is notable for nephrotoxicity and ototoxicity. None of these typically causes the lung-fibrosis-plus-pigmentation combination.
Answer: Option (3) — Bleomycin causes pulmonary fibrosis with skin pigmentation. (3)
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