Question:
Plasmacytoid lymphomas (lymphoplasmacytic lymphoma) may be associated with:
Plasmacytoid lymphomas (lymphoplasmacytic lymphoma) may be associated with:
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Think Waldenstrom macroglobulinemia and its large pentameric protein.
Updated On: Jun 24, 2026
- IgG
- IgM
- IgA
- IgE
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The Correct Option is B
Solution and Explanation
Step 1: Identify the tumour. A plasmacytoid or lymphoplasmacytic lymphoma is a B-cell lymphoma whose cells differentiate toward plasma cells and secrete a monoclonal immunoglobulin.
Step 2: Link it to the clinical syndrome. When this lymphoma secretes monoclonal IgM, it produces Waldenstrom macroglobulinemia. Macroglobulin literally means the large IgM molecule.
Step 3: Explain why IgM fits. IgM is a large pentamer. High levels of IgM thicken the blood, causing the hyperviscosity syndrome of Waldenstrom: visual blurring, headache, and bleeding. This is the classic association tested here.
Step 4: Reject the other classes. IgG is the class of typical multiple myeloma, not plasmacytoid lymphoma. IgA myeloma also exists but is a plasma cell tumour, not a lymphoplasmacytic lymphoma. IgE myeloma is exceedingly rare and unrelated.
Conclusion: Plasmacytoid (lymphoplasmacytic) lymphoma is associated with IgM. The answer is option B.
Step 2: Link it to the clinical syndrome. When this lymphoma secretes monoclonal IgM, it produces Waldenstrom macroglobulinemia. Macroglobulin literally means the large IgM molecule.
Step 3: Explain why IgM fits. IgM is a large pentamer. High levels of IgM thicken the blood, causing the hyperviscosity syndrome of Waldenstrom: visual blurring, headache, and bleeding. This is the classic association tested here.
Step 4: Reject the other classes. IgG is the class of typical multiple myeloma, not plasmacytoid lymphoma. IgA myeloma also exists but is a plasma cell tumour, not a lymphoplasmacytic lymphoma. IgE myeloma is exceedingly rare and unrelated.
Conclusion: Plasmacytoid (lymphoplasmacytic) lymphoma is associated with IgM. The answer is option B.
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