Oral vaccine such as Dukoral® and Shanchol™ is used for prevention of:
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- $ \text{Pneumonia} $
- $ \text{Ebola virus} $
- $ \text{Cholera} $
- $ \text{Polio} $
The Correct Option is C
Approach Solution - 1
Dukoral® and Shanchol™ are oral cholera vaccines designed to prevent cholera infection caused by Vibrio cholerae.
These vaccines stimulate mucosal immunity by inducing secretory IgA antibodies in the intestine, providing protection against cholera toxin. -
Dukoral® contains inactivated whole-cell Vibrio cholerae and recombinant cholera toxin B subunit.
Shanchol™ is a bivalent whole-cell oral vaccine without the toxin component.
These vaccines are effective in controlling cholera outbreaks, especially in endemic areas.
Other options:
Pneumonia vaccines target bacterial or viral causes like Streptococcus pneumoniae.
Ebola virus vaccine is different and not oral.
Polio vaccines (OPV) are oral but distinct from Dukoral/Shanchol.
Approach Solution -2
The question asks which disease Dukoral and Shanchol, both oral vaccines, are meant to prevent. Let's check each option:
- Pneumonia: Vaccines against pneumonia, such as the pneumococcal conjugate vaccine, target Streptococcus pneumoniae and are given by injection, not as an oral dose. Dukoral and Shanchol do not match this description.
- Ebola virus: Ebola vaccines, such as rVSV-ZEBOV, are viral vector vaccines given by injection to protect against the Ebola virus. This is unrelated to Dukoral or Shanchol.
- Cholera: Dukoral and Shanchol are both oral cholera vaccines built from inactivated whole cells of Vibrio cholerae. They work by producing local immunity, mainly secretory IgA antibodies, in the lining of the intestine, the exact site where the cholera bacterium attaches and produces its toxin.
- Polio: The oral vaccine for polio is a live attenuated vaccine developed by Sabin, made from poliovirus strains. Dukoral and Shanchol contain no poliovirus components and are unrelated products.
Both Dukoral and Shanchol are given by mouth specifically to build gut immunity against Vibrio cholerae, which is what causes cholera.
So the correct answer is Cholera.
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SymbolsList II
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