Concept:
Day 21 of a 28-day cycle lies in the luteal phase. In the luteal phase, the corpus luteum secretes progesterone. FSH and LH are suppressed by negative feedback.
Step 1: Identify the phase.
Ovulation occurs around day 14. Day 21 is after ovulation, so it is the:
\[
\text{Luteal phase}
\]
Step 2: Identify the dominant hormone.
The corpus luteum produces progesterone:
\[
P \uparrow
\]
Step 3: Understand feedback effect.
Progesterone suppresses pituitary gonadotropins:
\[
FSH \downarrow, \quad LH \downarrow
\]
Among the given options, the best matching profile is:
\[
\uparrow P, \downarrow E, \downarrow FSH, \downarrow LH
\]
Therefore, the correct answer is Option B.