Question

In an experimental study, blood glucose levels were elevated to 2--3 times the normal and maintained at that level. What is the most likely pattern of insulin secretion in response?

• A. Rapid rise followed by a fall
• B. Gradual rise followed by a fall
• C. Remains persistently elevated
• D. Initial rise followed by sustained elevation

Hint:

Insulin response to sustained glucose is biphasic: early rapid peak followed by sustained secretion.

Answer 1

The Correct Option is D

Concept: Insulin secretion in response to sustained high glucose is biphasic. There is an initial rapid release of preformed insulin followed by a sustained second phase due to new insulin release.

Step 1: Identify the stimulus.
Blood glucose is increased and maintained at a high level.

Step 2: Recall biphasic insulin response.
First phase: \[ \text{Rapid insulin release from stored granules} \] Second phase: \[ \text{Sustained insulin secretion} \]

Step 3: Choose the pattern.
The correct pattern is: \[ \text{Initial rise followed by sustained elevation} \] Therefore, the correct answer is Initial rise followed by sustained elevation.