Step 1: Understanding the Concept:
The adaptive immune system of teleost fish is divided into humoral immunity and cell-mediated immunity.
Step 2: Detailed Explanation:
T-lymphocytes (T-cells) are the primary cells responsible for cell-mediated immunity. They recognize intracellular pathogens, destroy infected host cells, and help coordinate the overall adaptive immune response.
B-lymphocytes (B-cells) are responsible for humoral immunity, primarily producing antibodies (immunoglobulins) against extracellular pathogens.
Macrophages are phagocytic cells of the innate immune system that act as antigen-presenting cells but do not drive adaptive cell-mediated immunity.
Red blood cells transport oxygen and are not principal immune cells.
Step 3: Final Answer:
T-lymphocytes are the main cell type responsible for cell-mediated immunity in fish.