Among illicit psychoactive substances, Cannabis (marijuana) is the most widely used drug worldwide.
It is commonly consumed for its psychoactive effects, and dependence can develop with regular use.
While Opium, Cocaine, and Amphetamines are also used illicitly, their global prevalence of use is lower compared to Cannabis.
Cannabis has both recreational and, in some countries, medicinal uses, which contributes to its widespread prevalence.
Hence, Cannabis is considered the most commonly used drug of dependence globally.