Question:
Methyldopa is primarily used in:
Methyldopa is primarily used in:
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This central antihypertensive is chosen for its safety in a specific patient group, not for its strength.
Updated On: Jun 24, 2026
- Parkinsonism
- Pregnancy induced hypertension
- Hirsutism
- Refractory hypertension
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The Correct Option is B
Solution and Explanation
Step 1: Recall the mechanism. Methyldopa is a centrally acting antihypertensive. It is converted to alpha-methylnoradrenaline, which stimulates central \(\alpha_2\) adrenergic receptors, reducing sympathetic outflow and lowering blood pressure.
Step 2: Apply the safety profile to pregnancy. Methyldopa has a long track record of safe use in pregnancy with no proven harm to the fetus, so it is a first-line drug for pregnancy induced hypertension and chronic hypertension in pregnancy.
Step 3: Rule out the others. Parkinsonism (A) is treated with levodopa, not methyldopa. Hirsutism (C) involves antiandrogens such as spironolactone or finasteride. Refractory hypertension (D) needs combination therapy and stronger agents; methyldopa is too weak and has too many side effects to be a mainstay there.
Answer: Option B (Pregnancy induced hypertension).
Step 2: Apply the safety profile to pregnancy. Methyldopa has a long track record of safe use in pregnancy with no proven harm to the fetus, so it is a first-line drug for pregnancy induced hypertension and chronic hypertension in pregnancy.
Step 3: Rule out the others. Parkinsonism (A) is treated with levodopa, not methyldopa. Hirsutism (C) involves antiandrogens such as spironolactone or finasteride. Refractory hypertension (D) needs combination therapy and stronger agents; methyldopa is too weak and has too many side effects to be a mainstay there.
Answer: Option B (Pregnancy induced hypertension).
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