Question

Match the LIST-I with LIST-II

• A. A-III, B-I, C-IV, D-II
• B. A-I, B-II, C-III, D-IV
• C. A-II, B-III, C-IV, D-I
• D. A-IV, B-II, C-I, D-III

Hint:

Compartmentalization:
Glycolysis = Cytosol (II).
TCA Cycle = Mitochondria (I).
Urea Cycle = Both Mitochondria and Cytosol (III).
Gluconeogenesis = Liver and kidney (IV).

Answer 1

The Correct Option is A

Step 1: Understanding the Question:
The question asks to match major metabolic pathways in LIST-I with their primary subcellular compartments or major organ sites in LIST-II.

Step 2: Key Formula or Approach:
Match metabolic pathways to their sub-cellular/organ locations:
• Urea Cycle: Partitioned between mitochondrial matrix and cytosol.

• Citric Acid Cycle: Matrix of mitochondria.

• Gluconeogenesis Glycogen storage: Liver and muscle tissue contexts.

• Glycolysis: Soluble cytosol.

Step 3: Detailed Explation:

• A. Urea Cycle $\to$ III. Mitochondria and cytosol: First two reactions (CPS-I and OTC) occur in the mitochondrial matrix; subsequent reactions occur in the cytosol.

• B. Citric acid cycle $\to$ I. Mitochondria: All TCA cycle enzymes reside in the mitochondrial matrix (except succite dehydrogese embedded in inner membrane).

• C. Gluconeogenesis $\to$ IV. Liver and muscles: Occurs predomintly in the liver (and kidney cortex) to synthesize glucose for extrahepatic tissues.

• D. Glycolysis $\to$ II. Cytosol: All ten glycolytic enzymes are located in the cytoplasm/cytosol.

Step 4: Fil Answer:
The correct matching sequence is A-III, B-I, C-IV, D-II.