Step 1: Analyze Column I terms.
- Active acquired immunity: Immunity developed after exposure to pathogens (direct contact with pathogens). $⇒$ (ii).
- First line of defense: Physical and chemical surface barriers like skin, mucous membranes. $⇒$ (iii).
- Passive natural immunity: Antibodies passed from mother to child across the placenta. $⇒$ (iv).
- Second line of defense: Innate immune responses involving complement proteins, interferons, phagocytes. $⇒$ (i).
Step 2: Compile the matches.
P–(ii), Q–(iii), R–(iv), S–(i).
Therefore, the correct answer is (A).