Question

Match the following: 

List-I	List-II
A. Linkage	I. Common in cancer cells
B. Recombination	II. Parental gene combination
C. Point mutation	III. Non-parental combination
D. Chromosomal aberration	IV. Sickle cell anemia
	V. Multiple phenotypes

• A. A-II, B-V, C-IV, D-I
• B. A-II, B-III, C-IV, D-I
• C. A-I, B-IV, C-III, D-V
• D. A-II, B-III, C-IV, D-V

Hint:

Linkage preserves parental combinations, recombination produces new combinations, and sickle cell anemia is caused by a point mutation.

Answer 1

The Correct Option is B

Concept: Genetic variations arise due to mutations, recombination and chromosomal changes. Each phenomenon has characteristic outcomes and biological significance.

Step 1: Match Linkage. Linkage refers to the tendency of genes present on the same chromosome to be inherited together. This preserves parental gene combinations. Thus: \[ A \rightarrow II \]

Step 2: Match Recombination. Recombination generates new gene combinations through crossing over. These combinations are non-parental. Thus: \[ B \rightarrow III \]

Step 3: Match Point Mutation. Sickle cell anemia results from a single nucleotide substitution in the \(\beta\)-globin gene. Hence it is a classical example of point mutation. Thus: \[ C \rightarrow IV \]

Step 4: Match Chromosomal Aberration. Chromosomal abnormalities are frequently associated with cancer cells. Examples include translocations and deletions. Thus: \[ D \rightarrow I \]

Step 5: Final matching. \[ A-II,\; B-III,\; C-IV,\; D-I \] Hence option (B) is correct.