Question

Match the following.

\[ \begin{array}{|c|l|c|l|} \hline & \textbf{Disease / Application} & & \textbf{Molecular Basis / Use} \\ \hline A & \text{Sickle Cell Anemia} & I & \text{Frameshift Mutation} \\ B & \text{Thalassemia} & II & \text{Missense Point Mutation} \\ C & \text{Duchenne Muscular Dystrophy} & III & \beta\text{-globin Gene Defect} \\ D & \text{PCR} & IV & \text{DNA Amplification Technique} \\ \hline \end{array} \]

The correct matching is

• A. A -- II, B -- III, C -- I, D -- IV
• B. A -- III, B -- II, C -- I, D -- IV
• C. A -- II, B -- I, C -- III, D -- IV
• D. A -- I, B -- III, C -- II, D -- IV

Hint:

Remember: \[ \boxed{ \begin{aligned} \text{Sickle cell anemia} &\rightarrow \text{Missense mutation} \text{Thalassemia} &\rightarrow \beta\text{-globin defect} \text{Duchenne muscular dystrophy} &\rightarrow \text{Frameshift mutation} \text{PCR} &\rightarrow \text{DNA amplification} \end{aligned} } \]

Answer 1

The Correct Option is A

Step 1: Recall the molecular basis of each disease. \[ \boxed{ \begin{aligned} \text{Sickle cell anemia} &\rightarrow \text{Missense point mutation} \text{Thalassemia} &\rightarrow \beta\text{-globin gene defect} \text{Duchenne muscular dystrophy} &\rightarrow \text{Frameshift mutation} \text{PCR} &\rightarrow \text{DNA amplification technique} \end{aligned} } \]

Step 2: Match List-I with List-II. Thus, \[ \boxed{ A-\mathrm{II},\; B-\mathrm{III},\; C-\mathrm{I},\; D-\mathrm{IV} } \] Therefore, \[ \boxed{(A)} \] is the correct answer.