Question

Match the biomolecules in Column I with their function given in Column II.

Column I	Column II
P. Lectins	1. Acts as ATP dependent pump to efflux out small molecules
Q. P-glycoprotein	2. Targets lysosomal enzymes to their destination
R. Digitoxigenin	3. Specific carbohydrate binding proteins
S. Mannose 6-phosphate	4. Inhibits Na+-K+ pump

• A. P-3; Q-2; R-1; S-4
• B. P-1; Q-3; R-4; S-2
• C. P-2; Q-1; R-3; S-4
• D. P-3; Q-1; R-4; S-2

Hint:

Think of each molecule's single defining role: sugar binding, drug efflux, pump inhibition, or lysosomal sorting.

Answer 1

The Correct Option is D

This question matches four biomolecules to their actual biological function. Go through each one in Column I and match the description in Column II that fits it.

1. P. Lectins: lectins are proteins that bind specific sugar (carbohydrate) groups on the surface of cells or other molecules, without being enzymes themselves. This is exactly description 3, specific carbohydrate binding proteins.
2. Q. P-glycoprotein: P-glycoprotein (P-gp, also called MDR1) is a membrane transporter from the ABC transporter family. It uses the energy of ATP hydrolysis to pump small drug molecules and other compounds out of the cell, which is the basis of multidrug resistance in cancer cells. This matches description 1, an ATP dependent pump that effluxes small molecules.
3. R. Digitoxigenin: digitoxigenin is a cardiac glycoside (steroid), related to digoxin, that binds and inhibits the Na⁺-K⁺ ATPase pump in cell membranes. Blocking this pump raises intracellular sodium and calcium, which is why cardiac glycosides increase the force of heart muscle contraction. This matches description 4, inhibits the Na⁺-K⁺ pump.
4. S. Mannose 6-phosphate: mannose 6-phosphate is a sugar tag added to lysosomal enzymes in the Golgi. Mannose 6-phosphate receptors recognize this tag and direct these enzymes from the Golgi to the lysosome. This matches description 2, targets lysosomal enzymes to their destination.

Putting these four matches together: P-3, Q-1, R-4, S-2. Checking the options, this combination is option (D).

Let's summarize:

• Lectins bind specific sugars on cell surfaces.
• P-glycoprotein is an ATP powered efflux pump for small molecules.
• Digitoxigenin is a cardiac glycoside that blocks the Na-K pump.
• Mannose 6-phosphate tags enzymes for lysosomal delivery.

So the correct match is P-3; Q-1; R-4; S-2, which is option (D).