Question

Match List-I with List-II

List-I (Person product) & List-II (Description particulars)
(A) Louise Brown & (II) First IVF human baby
(B) Lulu Nana & (IV) First Genome-edited human baby
(C) Dolley & (III) First mammal cloned
(D) Flavr-Savr & (I) First Transgenic tomato

• (A) - (IV), (B) - (II), (C) - (I), (D) - (III)
• (A) - (II), (B) - (IV), (C) - (I), (D) - (III)
• (A) - (II), (B) - (IV), (C) - (III), (D) - (I)
• (A) - (III), (B) - (IV), (C) - (I), (D) - (II)

Hint:

Remember these biotechnology landmarks:
- Dolly the sheep: First somatic cell clone.
- Flavr Savr: First GM tomato.
- Lulu & Nana: First CRISPR gene-edited humans.

Answer 1

The Correct Option is C

Step 1: Understanding the Concept:
This matching question is based on historical milestones in reproductive biotechnology, genetic engineering, and genome editing.

Step 2: Detailed Explanation:
Let us pair each biological entity with its landmark historical description:
- (A) Louise Brown $\rightarrow$ (II) First IVF human baby:
Louise Brown, born on July 25, 1978, in Great Britain, was the world's first human baby born through successful in vitro fertilization (IVF).
- (B) Lulu Nana $\rightarrow$ (IV) First Genome-edited human baby:
Lulu and Nana are twin girls born in late 2018 in China.
They were the world's first CCR5-gene edited babies, created using CRISPR-Cas9 technology by scientist He Jiankui.
- (C) Dolley (Dolly) $\rightarrow$ (III) First mammal cloned:
Dolly the sheep, born in 1996 in Scotland, was the first mammal ever cloned from an adult somatic cell (using somatic cell nuclear transfer).
- (D) Flavr-Savr $\rightarrow$ (I) First Transgenic tomato:
The Flavr Savr tomato, released in 1994, was the first genetically modified food product approved for human consumption.
It was engineered to have a longer shelf life by introducing an antisense gene to inhibit polygalacturonase, which slows pectin degradation.
This results in the sequence: (A)-(II), (B)-(IV), (C)-(III), (D)-(I).

Step 3: Final Answer:
The correct matching sequence is (A) - (II), (B) - (IV), (C) - (III), (D) - (I).