Question:
Low CSF protein may be seen in all of the following conditions, except:
Low CSF protein may be seen in all of the following conditions, except:
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Myxedema raises CSF protein, it does not lower it.
Updated On: Jun 24, 2026
- Recurrent lumbar puncture
- Hypothyroidism
- Pseudotumor cerebri
- Infants
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The Correct Option is B
Solution and Explanation
Step 1: Normal CSF protein in adults is roughly 15 to 45 mg/dL. The question asks which listed condition does not cause a low CSF protein.
Step 2: Recurrent or repeated lumbar punctures and chronic CSF leak drain protein-containing fluid faster than it is replaced, so CSF protein falls. This is a recognised cause of low CSF protein.
Step 3: Pseudotumor cerebri (idiopathic intracranial hypertension) classically shows raised CSF pressure with normal or low CSF protein; a low value is a typical accepted finding. Young infants normally have low CSF protein production patterns in some references and are listed as a low-protein group.
Step 4: Hypothyroidism (myxedema) is associated with an increased CSF protein, not a decreased one. It is a known cause of elevated CSF protein. Therefore it does not belong with the low-protein conditions.
Step 5: The exception is hypothyroidism.
Answer: Option B (Hypothyroidism).
Step 2: Recurrent or repeated lumbar punctures and chronic CSF leak drain protein-containing fluid faster than it is replaced, so CSF protein falls. This is a recognised cause of low CSF protein.
Step 3: Pseudotumor cerebri (idiopathic intracranial hypertension) classically shows raised CSF pressure with normal or low CSF protein; a low value is a typical accepted finding. Young infants normally have low CSF protein production patterns in some references and are listed as a low-protein group.
Step 4: Hypothyroidism (myxedema) is associated with an increased CSF protein, not a decreased one. It is a known cause of elevated CSF protein. Therefore it does not belong with the low-protein conditions.
Step 5: The exception is hypothyroidism.
Answer: Option B (Hypothyroidism).
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