Question:
Leiden thrombophilia is caused by a mutational deficiency involving which of the following factors?
Leiden thrombophilia is caused by a mutational deficiency involving which of the following factors?
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The name says it - factor V Leiden is APC-resistant factor V, the commonest inherited thrombophilia.
Updated On: Jun 23, 2026
- Factor V
- Factor VII
- Factor IX
- Factor X
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The Correct Option is A
Solution and Explanation
Step 1: Factor V Leiden thrombophilia is the most common inherited cause of a hypercoagulable state. The name itself points to the affected clotting protein - factor V - so option (a) is correct.
Step 2: The defect is a point mutation (Arg506Gln) in the factor V gene. This mutated factor V resists cleavage and inactivation by activated protein C (APC resistance). Because the natural "brake" cannot switch factor V off, the clotting cascade stays active and abnormal venous clots form more easily.
Step 3: The distractors name other coagulation factors that cause different disorders: factor VII deficiency, factor IX deficiency (haemophilia B), and factor X deficiency all cause bleeding tendencies, the opposite of the clotting tendency seen in factor V Leiden. None of them is the Leiden mutation.
Step 2: The defect is a point mutation (Arg506Gln) in the factor V gene. This mutated factor V resists cleavage and inactivation by activated protein C (APC resistance). Because the natural "brake" cannot switch factor V off, the clotting cascade stays active and abnormal venous clots form more easily.
Step 3: The distractors name other coagulation factors that cause different disorders: factor VII deficiency, factor IX deficiency (haemophilia B), and factor X deficiency all cause bleeding tendencies, the opposite of the clotting tendency seen in factor V Leiden. None of them is the Leiden mutation.
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