Question:
Leiden thrombophilia is caused by a mutational abnormality of which of the following factors?
Leiden thrombophilia is caused by a mutational abnormality of which of the following factors?
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The condition's own name reveals the clotting factor.
Updated On: Jun 24, 2026
- Factor V
- Factor VII
- Factor IX
- Factor X
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The Correct Option is A
Solution and Explanation
Step 1: Identify the condition. Factor V Leiden thrombophilia is an inherited disorder of blood clotting and is the most common inherited form of thrombophilia.
Step 2: Define the mutation. Factor V Leiden is a specific point mutation in the gene for clotting Factor V.
Step 3: Explain the effect. The mutated Factor V resists inactivation by activated protein C, so clotting is no longer switched off properly, producing an increased tendency to form abnormal clots (thrombophilia).
Step 4: Why the distractors are wrong. Factors VII, IX, and X are not the basis of Leiden thrombophilia; the very name of the condition points to Factor V.
Step 2: Define the mutation. Factor V Leiden is a specific point mutation in the gene for clotting Factor V.
Step 3: Explain the effect. The mutated Factor V resists inactivation by activated protein C, so clotting is no longer switched off properly, producing an increased tendency to form abnormal clots (thrombophilia).
Step 4: Why the distractors are wrong. Factors VII, IX, and X are not the basis of Leiden thrombophilia; the very name of the condition points to Factor V.
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