Question:
Lasmiditan is an agonist at which serotonin receptor subtype?
Lasmiditan is an agonist at which serotonin receptor subtype?
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Serotonin (5-HT) receptors have many subtypes, and different anti-migraine drugs target different ones. Knowing the exact subtype helps explain a drug's selectivity and side-effect profile.
Updated On: Jun 24, 2026
- 5-HT1A
- 5-HT1D/1B
- 5-HT1F
- 5-HT2A/2c
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The Correct Option is C
Solution and Explanation
Concept:
Serotonin (5-HT) receptors have many subtypes, and different anti-migraine drugs target different ones. Knowing the exact subtype helps explain a drug's selectivity and side-effect profile.
How it works: Lasmiditan is a selective 5-HT1F receptor agonist (a "ditan"). By acting on 5-HT1F receptors, it reduces the release of inflammatory neuropeptides and dampens trigeminal pain signalling in migraine, without causing blood-vessel constriction.
Why this matters: Older triptans act on 5-HT1B/1D receptors, which causes vasoconstriction and limits their use in patients with cardiovascular disease. Lasmiditan's 5-HT1F selectivity avoids this vascular effect, which is its main clinical advantage.
Answer: Option (3) — Lasmiditan is a selective 5-HT1F receptor agonist. (3)
Serotonin (5-HT) receptors have many subtypes, and different anti-migraine drugs target different ones. Knowing the exact subtype helps explain a drug's selectivity and side-effect profile.
How it works: Lasmiditan is a selective 5-HT1F receptor agonist (a "ditan"). By acting on 5-HT1F receptors, it reduces the release of inflammatory neuropeptides and dampens trigeminal pain signalling in migraine, without causing blood-vessel constriction.
Why this matters: Older triptans act on 5-HT1B/1D receptors, which causes vasoconstriction and limits their use in patients with cardiovascular disease. Lasmiditan's 5-HT1F selectivity avoids this vascular effect, which is its main clinical advantage.
Answer: Option (3) — Lasmiditan is a selective 5-HT1F receptor agonist. (3)
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