Question

Kayser Fleischer rings (KF rings) are seen in:

• A. Pterygium
• B. Hemochromatosis
• C. Wilson's disease
• D. Menkes kinky hair syndrome

Hint:

Copper ring in the cornea means a copper overload disease.

Answer 1

The Correct Option is C

Step 1: Identify the sign. A Kayser Fleischer ring is a golden brown to greenish ring at the periphery of the cornea, caused by copper deposition in Descemet's membrane.
Step 2: Link copper to disease. Wilson's disease is a disorder of copper metabolism (defect in the ATP7B gene) where copper accumulates in the liver, brain and cornea. The corneal copper produces the KF ring, so KF rings are a classic sign of Wilson's disease.
Step 3: Recall the wider picture. Wilson's disease presents with liver disease, neuropsychiatric features (tremor, dystonia, behavioural change) and KF rings. Low serum ceruloplasmin and high urinary copper support the diagnosis.
Step 4: Exclude the distractors. Pterygium is a fleshy conjunctival growth, unrelated to copper. Hemochromatosis is iron overload, not copper, and does not cause KF rings. Menkes kinky hair syndrome is a copper deficiency disorder (failure to absorb copper) with kinky hair and is the opposite metabolic problem, not associated with KF rings.
Conclusion: Kayser Fleischer rings are seen in Wilson's disease, option C.