Question:
Integrase inhibitor approved for treatment of HIV is?
Integrase inhibitor approved for treatment of HIV is?
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The integrase inhibitor class carries the suffix -gravir.
Updated On: Jun 24, 2026
- Raltegravir
- Indinavir
- Lopinavir
- Tipranavir
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The Correct Option is A
Solution and Explanation
Step 1: Integrase is an HIV enzyme that catalyses insertion of the reverse-transcribed viral DNA into the host cell genome. Integrase strand transfer inhibitors (INSTIs) block this step.
Step 2: Raltegravir was the first integrase inhibitor approved (2007) for HIV treatment. The drug name suffix -gravir identifies the integrase inhibitor class (e.g., raltegravir, dolutegravir, elvitegravir, bictegravir).
Step 3: The remaining options are protease inhibitors, recognisable by the -navir suffix: Indinavir, Lopinavir and Tipranavir all block the HIV protease enzyme that cleaves polyprotein precursors during viral maturation, not integrase.
Conclusion: The correct answer is Raltegravir, matching the printed key.
Step 2: Raltegravir was the first integrase inhibitor approved (2007) for HIV treatment. The drug name suffix -gravir identifies the integrase inhibitor class (e.g., raltegravir, dolutegravir, elvitegravir, bictegravir).
Step 3: The remaining options are protease inhibitors, recognisable by the -navir suffix: Indinavir, Lopinavir and Tipranavir all block the HIV protease enzyme that cleaves polyprotein precursors during viral maturation, not integrase.
Conclusion: The correct answer is Raltegravir, matching the printed key.
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