Comprehension

Read the following passage and answer the questions based on it.

Eye surgeon Virendar Sangwan has perfected a procedure so cutting-edge that most who have tried it have failed. In an operating theatre in the central Indian city of Hyderabad, he surgically implants corneas grown in a petri dish from stem cells by his colleague Geeta Vemuganti in patients with damaged eyes. Together they perform about 80 corneal regeneration procedures a year, making the L.V. Prasad Eye Institute, where they work, one of the most prolific facilities in the world using stem cells to regenerate tissues of any kind.

The Sangwan-Vemuganti team uses stem cells found in the tissues of living adults, not ones derived from embryos. Teams all over the world are working with adult stem cells, trying to coax them to regrow cells in hearts, brains, livers and other organs, but progress is slow. Besides corneas, scientists have had some success regrowing skin cells and bone tissues, but those procedures remain experimental. "A number of programs around the world have tried to perfect this treatment, but they have had bad outcomes," says University of Cincinnati eye surgeon and stem cell specialist Edward Holland. "It is impressive what they are doing at Prasad." In addition to the Hyderabad project, only Holland's program and a half-dozen others in the world conduct operations using corneas grown from stem cells. The treatment uses stem cells harvested from the limbus, located where the cornea touches the white of the eye. For those with damaged corneas, these cells, called "limbic" and "conjunctiva", are harvested from a patient's good eye, if he has one, or from a close relative. They are placed in a petri dish and chemically tweaked to grow into the lower layer of a cornea, called epithelium. It is then transplanted into the eye of the patient where in most cases it takes hold and grows. In 56% of the cases at the Prasad Institute, the patient could still see clearly 40 months later.

Indians are well known for reverse engineering, meaning they can deduce how drugs are made in order to produce generic versions. But in this case, Sangwan and Vemuganti, a pathologist, developed the technique on their own from reading papers and running experiments in the lab. Sangwan says he had a number of patients with burned eyes who could not be helped with standard corneal transplants from cadavers, so he persuaded Vemuganti to try growing corneas in her lab. "You know how to grow cells, and I know how to do the transplant surgery," Vemuganti recalls him saying. "Why don't we work together?" She smiles and shakes her head. "I had no clue if this was going to work." Vemuganti's major innovation was developing a platform on which to grow corneas. First she designed a circular glass tube about the size of a stack of coins. Then she overlaid the glass with tissue from a human placenta, which is "a good surface to grow corneas on," she says. After that she placed stem cells in four places around a circle, added a growth medium, and watched the corneas begin to grow. Commercial interest among stem cell companies for the procedure has been scant because of the perceived small volume of patients, says venture capitalist Antoun Nabhan, who sits on the board of Cellerant, a leading stem cell company in San Carlos, California. But corneal stem cell treatment may have wider applications, says ophthalmologist Ivan Schwab of the University of California at Davis. "These stem cells are similar to others in the body that make mucous membrane," he says. "These techniques of growing stem cells might one day be used to treat mucous-membrane tissue in the sinuses, bladder, and other organs."

Question: 1

According to the article, Sangwan-Vemuganti team's cutting-edge procedure of implanting cornea grown from stem cells is considered a major advancement by the experts because

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Contrast the phrase "not ones derived from embryos" with what other teams elsewhere are attempting, and note the team's success is specific to corneas.
Updated On: Jul 14, 2026
  • They derive stem cells from embryos.
  • Their labs are customised to grow stem cells.
  • They regrow cells in hearts, brains, livers with stem cells from tissues of living adults.
  • They derive stem cells from tissues of living adults and grow cells in labs.
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The Correct Option is D

Solution and Explanation

Step 1: Understand what the question is asking.
The question asks why experts see the Sangwan-Vemuganti procedure as a major advance. The answer has to come straight from what the passage says makes their method different from other stem cell work happening elsewhere.

Step 2: Locate the relevant lines in the passage.
The passage says the team "uses stem cells found in the tissues of living adults, not ones derived from embryos," and that they grow these cells into working corneal tissue in the lab, with about 80 successful procedures a year.

Step 3: Match this against the options.
Option 1 is wrong because the passage explicitly rules out embryonic stem cells. Option 2 is wrong because the advance is not about customised labs, it is about the source and success of the cells. Option 3 is wrong because regrowing hearts, brains and livers is what other teams around the world are attempting with slow progress, not what Sangwan and Vemuganti achieved; their success is specifically with corneas. Option 4 correctly states that they take stem cells from living adults and grow them into functioning tissue in the lab, which is exactly what the passage credits as the breakthrough.

Final Answer:
The team's advance lies in using adult, not embryonic, stem cells and successfully growing them into corneal tissue in the lab. \[ \boxed{\text{They derive stem cells from tissues of living adults and grow cells in labs}} \]
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Question: 2

Sangwan-Vemuganti procedure is carried out on

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Match the exact phrase in the passage, patients with damaged eyes, rather than a broader or narrower rewording.
Updated On: Jul 14, 2026
  • Patients requiring any corneal transplant
  • Patients with damaged corneas
  • Patients with damaged eyes of any kind
  • None of the above
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The Correct Option is C

Solution and Explanation

Step 1: Understand the question.
The question asks which group of patients the Sangwan-Vemuganti procedure is meant for, so the answer must match the exact patient group named in the passage, not a broader or narrower group.

Step 2: Find the exact phrase in the passage.
The passage states that Sangwan "surgically implants corneas grown in a petri dish from stem cells... in patients with damaged eyes." This is the direct description of who receives the procedure.

Step 3: Compare each option to this phrase.
Option 1 says "any corneal transplant," which is too broad, since the passage is about this specific stem-cell method, not every kind of corneal transplant. Option 2 narrows the group to only "damaged corneas," but the passage uses the wider phrase "damaged eyes." Option 3 matches the passage word for word: patients with damaged eyes. Option 4 is ruled out because option 3 is directly supported by the text.

Final Answer:
The passage names the patient group as those with damaged eyes, which is option 3. \[ \boxed{\text{Patients with damaged eyes of any kind}} \]
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Question: 3

The world recognises this Indian innovation because Indian scientists are normally known

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Reverse engineering means working backward from a finished drug to figure out how it was made.
Updated On: Jul 14, 2026
  • To be good at analysing and finding out a method of how an existing drug is made.
  • As they are good researchers of drugs.
  • As they are good at carrying out experiments to create generic drugs.
  • As they are able to carry out drug trials on large samples.
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The Correct Option is A

Solution and Explanation

This question asks why the world takes special notice of what Sangwan and Vemuganti achieved, tying it to a reputation Indian scientists already have. The passage spells out that reputation in one sentence, so the task is to match it to the right option.

  1. To be good at analysing and finding out a method of how an existing drug is made: The passage says "Indians are well known for reverse engineering, meaning they can deduce how drugs are made in order to produce generic versions." Deducing how something already made works is exactly analysing and finding out its method, so this matches.
  2. As they are good researchers of drugs: This is too vague and is not what the passage credits Indians with; the text is specific about reverse engineering existing drugs, not general drug research.
  3. As they are good at carrying out experiments to create generic drugs: This shifts the emphasis to the experiments themselves rather than the analytical skill of figuring out how a drug was made, which is the actual point the passage makes.
  4. As they are able to carry out drug trials on large samples: Drug trials are not mentioned anywhere in the passage in connection with this reputation.

Since reverse engineering means working backward from a finished drug to figure out its method of manufacture, the first option is the one that actually describes this skill.

Let's summarize:

  • Reverse engineering is about analysing an existing product to find out how it was made, not inventing something new.
  • The passage ties this reputation to producing generic drug versions after reverse engineering the originals.

The correct answer is that Indians are known for analysing and finding out the method behind an existing drug, option (A).

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Question: 4

The pathologist, Vemuganti, started growing cornea in a petri dish

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The passage credits both reading published papers and running her own experiments; look for the option that keeps both parts.
Updated On: Jul 14, 2026
  • By following procedures published in research papers
  • By inventing a totally new procedure
  • By experimenting with procedures published in journals
  • By following the instruction of the transplant surgeon
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The Correct Option is C

Solution and Explanation

Step 1: Understanding the Question.
The question asks how Vemuganti, the pathologist, actually arrived at her method for growing corneas in a petri dish, based on what the passage tells us about her process.

Step 2: Locate the relevant sentence.
The passage says Sangwan and Vemuganti "developed the technique on their own from reading papers and running experiments in the lab." This mentions two things together: reading published research and then testing it hands-on in the lab.

Step 3: Match this to the options.
Option 1 mentions only "following procedures published in research papers," which misses the hands-on experimentation part and makes it sound passive. Option 2, "inventing a totally new procedure," is wrong because the passage says they built on papers they had read, not something from nothing. Option 3, "experimenting with procedures published in journals," captures both halves correctly: procedures that came from published journal papers, tested through her own experiments. Option 4 is unsupported, since Vemuganti worked out the growing method herself; the surgeon only proposed that they collaborate.

Final Answer:
Vemuganti combined reading published research with her own lab experiments, which matches option 3. \[ \boxed{\text{By experimenting with procedures published in journals}} \]
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Question: 5

In the context of the passage, choose the correct set of meanings for the words: PLATFORM and GENERIC

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Read platform as the growing system Vemuganti built, and generic in the drug sense of no brand name.
Updated On: Jul 14, 2026
  • Lab table; related to genes
  • Method; related to genes
  • Lab experiments; without a brand name
  • Methodology; without a brand name
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The Correct Option is D

Solution and Explanation

Step 1: Understanding the Question.
The question asks for the meaning of two words as they are actually used in the passage: "platform" and "generic." Both words have everyday meanings that do not fit here, so context has to decide the answer.

Step 2: Work out "platform" from its sentence.
The passage says Vemuganti's "major innovation was developing a platform on which to grow corneas," and then describes this platform as a whole system: a glass tube, a placenta tissue surface, and stem cells placed in a growth medium. This is a systematic procedure, so "platform" here means a method or methodology, not a physical stage or lab table.

Step 3: Work out "generic" from its sentence.
The passage talks about Indians producing "generic versions" of drugs through reverse engineering. In this drug context, "generic" means a version of a drug sold without the original manufacturer's brand name, once the patent has expired.

Step 4: Match the pair to the options.
Option 1 makes "platform" a lab table and "generic" about genes, both wrong senses. Option 2 keeps "method" for platform but wrongly ties "generic" to genes. Option 3 gets "generic" right but wrongly reduces "platform" to lab experiments rather than a methodology. Option 4 pairs "methodology" with "without a brand name," matching both words correctly.

Final Answer:
Platform means methodology and generic means without a brand name, so the answer is option 4. \[ \boxed{\text{Methodology; without a brand name}} \]
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