Question:
In Wilson's disease, there is less urinary excretion of-
In Wilson's disease, there is less urinary excretion of-
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The printed key points to the muscle-turnover marker among these urinary substances.
Updated On: Jun 23, 2026
- Phosphorus
- Methyl-Histidine
- Phosphotyrosine
- Serine
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The Correct Option is B
Solution and Explanation
Step 1: Wilson's disease is an autosomal recessive disorder of copper metabolism (ATP7B mutation) that presents with chronic liver disease, neurologic deterioration, Kayser-Fleischer rings, low ceruloplasmin, and altered serum and urine copper. Step 2: The recalled answer for this item is methyl-histidine, a marker normally excreted in urine from the breakdown of muscle proteins. Step 3: As per the printed key, urinary methyl-histidine excretion is reduced in this clinical setting. Step 4: Phosphorus, phosphotyrosine, and serine are not the recalled answer, so among the options provided methyl-histidine is selected.
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