Step 1: Recall major mass extinction events.
- Cretaceous–Paleogene (K–Pg, 66 Ma): Caused by asteroid impact and volcanism (Deccan traps).
- Permian–Triassic (252 Ma): Largest extinction, linked to Siberian Traps volcanism, ocean anoxia, methane release.
- Ordovician–Silurian (445 Ma): Caused mainly by global cooling, Gondwana glaciation, and associated sea-level fall. This event wiped out more than 50% of marine fauna.
- Holocene (ongoing): Linked to human activities, not glaciation.
Step 2: Identify correct extinction.
Only the Ordovician–Silurian event was directly caused by global cooling, glaciation, and sea-level fall.
Final Answer:
\[
\boxed{\text{Ordovician – Silurian}}
\]